Mechanical properties of Pharmaceutical Formulations
Small differences in nanomechanical properties can cause significant changes the manufacturing performance of pharmaceuticals. In pharmaceuticals research, there is a continued push for an increased mechanistic understanding of raw material properties to have better control over drug efficacy, safety, cost and higher product reliability. For example, one active area of research is where tablets are used as a dosage form. In this case, single-crystal mechanical properties are critical and strongly influence their bulk compressibility and compactibility. Understanding the mechanical anisotropy of these materials is important to understanding manufacturing failures and optimizing materials and processes. Hysitron’s suite of nanoindentation techniques provides the ability to measure directional- dependent (i.e. anisotropic) mechanical properties of small volumes of pharmaceutical compounds.
Cellular Mechanical Response to Pharmaceuticals
Many pharmaceuticals have an effect on the mechanical properties of cells and tissues. This is evident for pharmaceuticals designed to alter mechanical properties, such as those for osteoporosis, osteoarthritis, and high blood pressure. However, drugs designed for non-mechanical property altering reasons may lead to mechanical property changes due to biochemical and structure modifications of cells. Consequently, measurement of mechanical biophysical changes within the cell can infer cell state and function. Hysitron has developed a comprehensive suite of nanoindentation testing techniques to accurately target individual cells/tissues containing active pharmaceutical compounds to directly correlate incipient mechanical properties.